to meet up
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Nina: Diana, hey, it's me, Nina. How are you doing? Are you going to be in the city this weekend?
Diana: Hey! Yeah!
Nina: Want to meet up?
Diana: You know it! There's a cute café down the street from my place. I'll text you the address. Can't wait!
This meme is making fun of the kinds of people who gather at meetups: in this case, computer geeks, sitting around coding and giggling. To chuckle means to laugh quietly or even to yourself.
However, you may sometimes hear it in the traditional sense of meeting up with friends: At our last meetup, Gary got drunk and made a spectacle of himself, so he's not coming to our next one.
More Examples:
Hey, do you want to meet up for lunch later?
—Sure, where do you want to go?
Heeey! Long time no see! Let's meet up soon — we've got some catching up to do!
—I mean! How about we meet up at the café by the bookstore this Saturday?
Hey, are you going to Evan's party tonight?
—Yep.
What do you say we meet up beforehand and go together?
—Sounds like a plan. See you then!
Hey, my brother's in town this weekend and we're having a little get-together on Sunday. We're just going to grill out and hang. Join us if you can.
— Nice. Can I bring anything?
Just yourself... and your bathing suit if you want to go swimming.
— Count on it!